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Download Aminoacyl-tRNA Synthetases in Biology and Medicine by Sunghoon Kim PDF

By Sunghoon Kim

ISBN-10: 940178700X

ISBN-13: 9789401787000

This publication will concentrate on new molecular interactions and novel actions and the linked illnesses which were lately came upon from the reports of eukaryotic and mammalian aminoacyl-tRNA synthetases. furthermore, the capability functions of ARS researches in biotechnology and drugs may be addressed.

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Additional resources for Aminoacyl-tRNA Synthetases in Biology and Medicine

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Cusack S (1997) Aminoacyl-tRNA synthetases. Curr Opin Struct Biol 7:881–889 37. Guo M, Schimmel P (2012) Structural analyses clarify the complex control of mistranslation by tRNA synthetases. Curr Opin Struct Biol 22:119–126 38. Tang SN, Huang JF (2005) Evolution of different oligomeric glycyl-tRNA synthetases. J. Perona and I. Gruic-Sovulj 39. Dock-Bregeon A, Sankaranarayanan R, Romby P, Caillet J, Springer M, Rees B, Francklyn CS, Ehresmann C, Moras D (2000) Transfer RNA-mediated editing in threonyl-tRNA synthetase.

Therefore, among all editing aaRS, IleRS may be unique with respect to this property [8, 47]. Further detailed structure–function studies of IleRS are needed to understand how tRNA enhancement of pre-transfer editing functions. An earlier model for tRNA-dependent pre-transfer editing, developed for editing of valine by IleRS, invoked a complex mechanism by which noncognate aminoacyl adenylates are shuttled to the CP1 domain editing site, so that this active site would catalyze both pre-transfer and post-transfer editing [182–185].

Structure 3:17–31 100. Eriani G, Delarue M, Poch O, Gangloff J, Moras D (1990) Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs. Nature 347:203–206 101. Cavarelli J, Eriani G, Rees B, Ruff M, Boeglin M, Mitschler A, Martin F, Gangloff J, Thierry JC, Moras D (1994) The active site of yeast aspartyl-tRNA synthetase: structural and functional aspects of the aminoacylation reaction. EMBO J 13:327–337 102. Dignam JD, Guo J, Griffith WP, Garbett NC, Holloway A, Mueser T (2011) Allosteric interaction of nucleotides and tRNA(ala) with E.

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