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Download Advances in Molecular Toxicology, Vol. 2 by James C. Fishbein PDF

By James C. Fishbein

ISBN-10: 0444530983

ISBN-13: 9780444530981

Advances in Molecular Toxicology good points the newest advances in the entire subspecialties of the vast zone of molecular toxicology. Toxicology is the learn of toxins and this sequence info the examine of the molecular foundation wherein an unlimited array of brokers encountered within the human atmosphere and produced by means of the human physique itself happen themselves as pollutants. now not strictly constrained to documenting those examples the sequence is usually taken with the complicated net of chemical and organic occasions that provide upward thrust to toxin-induced indicators and sickness. the recent applied sciences which are being harnessed to research and comprehend those occasions can also be reviewed by means of prime employees within the box. Advances in Molecular Toxicology will document growth in all points of those quickly evolving molecular points of toxicology with a view towards distinct elucidation of either development at the molecular point and on advances in technological methods hired * innovative stories via major staff within the self-discipline. * extensive dissection of molecular features of curiosity to a vast variety of scientists, physisicans and any scholar within the allied disciplines. * cutting edge purposes of technological concepts within the chemistry, biochemistry and molecular drugs.

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Kawanishi, S. Inoue, S. Sano, Mechanism of DNA cleavage induced by sodium chromate(VI) in the presence of hydrogen peroxide, J. Biol. Chem. 261 (1986) 5952–5958. J. Liu, J. Jiang, F. Goda, N. M. Swartz, Low frequency electron paramagnetic resonance investigations on metabolism of chromium(VI) by whole live mice, Ann. Clin. Lab. Sci. 26 (1996) 176–184. M. E. Wetterhahn, Reaction of chromium(VI) with ascorbate produces chromium(V), chromium(IV), and carbon-based radicals, Chem. Res. Toxicol. 7 (1994) 219–230.

4070 Basle, Switzerland ÃCorresponding author. V. All rights reserved. 25 26 ¨hler and Christoph Funk Axel Pa evaluation relate to (pre)clinical toxicity (animal toxicity approximately 20%), lack of clinical efficacy (approximately 25%) and commercial considerations (approximately 20%) [1]. Unmanageable pharmacokinetics and metabolism in man [2] was a major reason for discontinuation of new drugs in early clinical trials one to two decades ago. Our understanding of fundamental aspects in drug metabolism and disposition as well as the availability of predictive in vitro assays and in silico extrapolations to the in vivo situation have considerably contributed to reduce drug attrition due to poor pharmacokinetics in man.

D. Scharer, J. Jiricny, Recent progress in the biology, chemistry and structural biology of DNA glycosylases, Bioessays 23 (2001) 270–281. [83] S. Shibutani, M. P. Grollman, Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxo-dG, Nature 349 (1991) 431–434. T. C. G. L. R. J. M. Essigmann, The hydantoin lesions formed from oxidation of 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivo, Biochemistry 42 (2003) 9257–9262. T. C. Delaney, F. R.

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