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Extra resources for Advances in Immunology, Vol. 47
It is rather unlikely that GIF is a fragment of lipocortin. However, GIF shares common biochemical properties and an antigenic determinant with lipocortin. One may speculate that the phospholipase inhibitory activity of the lymphokine is important in its immunological functions. This idea was supported by recent findings that a synthetic inhibitor of phospholipase A2, 2(P-amylcennamoyl)-amino-4-chlorobenzoic acid, could switch a T cell hybridoma from the formation of IgE-PFs to the formation of IgE-SFs, while neomycin, a well-known phospholipase C inhibitor, did not.
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And Ishizaka, K. (1980a). J. Immunol. 125, 1442. , and Ishizaka, K. (1980b). J. Immunol. 125, 2154. , Yodoi, J.. and Ishizaka, K. J. Immunol. 126, 838. Hirashima, M . , and Ishizaka, K. J. Immunol. 127, 1804. Hirashima, M . , Huff, T. , and Ishizaka, K. J. Immunol. 127, 1810. Huff, T. , and Ishizaka, K. (1982). J. Immunol. 129, 509. Huff, T. , and Ishizaka, K. J. Immunol. 131, 1090. Huff, T. , and Ishizaka, K. J. Immunol. 132, 406. Huff, T. , Jardieu, R , and Ishizaka, K. (1986). J Immunol. 136, 955.